Arrhenius relationships from the molecule and cell to the clinic

By William C. Dewey. International Journal of Hyperthermia, 2009

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The cellular and molecular basis of hyperthermia. (2002, background): “In vitro and animal hyperthermic experiments exhibited a direct cell killing effect at temperatures ranging from 41 to 47 °C [27,36,37].”
Basic principles of thermal dosimetry and thermal thresholds for tissue damage from hyperthermia (2003, background): “(1) Thresholds are endpoint dependent.”
Hyperthermia in oncology. (2001, methodology): “…application of the thermal isoeffect dose (TID) concept has been applied in retrospective analyses of clinical data to guide future clinical studies in which different treating protocols for different times at different temperatures are converted into equivalent minutes at 43°C (Dewey 1994).”
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. (2008, background): “Here, temperatures in tumorloaded tissues are elevated to 40–43 C [47] and above by selective or non-selective application of microwave, radio, ultrasound, alternating magnetic, infrared, or visible radiation.”