Trafficking and function of the tetraspanin CD63.

By Maaike Pols, Judith Klumperman. Experimental Cell Research, 2009

754 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c47507ba7d27e08438b761952d0b7b567e44a981

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Citations in the corpus

Introduction to Extracellular Vesicles: Biogenesis, RNA Cargo Selection, Content, Release, and Uptake (2016, neutral): “First, the endosome membrane is reorganized such that it becomes highly enriched for tetraspanins (Pols and Klumperman 2009).”
Optimisation of imaging flow cytometry for the analysis of single extracellular vesicles by using fluorescence-tagged vesicles as biological reference material (2019, background): “Some tetraspanins, CD63 in particular, have been qualified as EV or “exosome”markers [60,61].”
Tetraspanins in Extracellular Vesicle Formation and Function (2014, background): “In fact, in many cells the bulk of CD63 has been described as typical in intracellular compartments of endosome/lysosomal origin (57).”
The tetraspanin CD63 regulates ESCRT-independent and dependent endosomal sorting during melanogenesis (2011, background): “…predominantly to late endosomes and lysosomes (Pols and Klumperman, 2009), whereas in specialized cells CD63 is also present in LROs such as endothelial cell Weibel Palade Bodies, platelet dense granules and neutrophil myeloperoxidase granules (Pols and Klumperman, 2009; Raposo and Marks, 2007).”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “The process of ILV formation starts when the endosomal membrane is reorganized into specialized tetraspanins-enriched microdomains (TEMs), with the involvement of CD9 and CD63, that function to cluster the ILV formation machinery [49].”
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, neutral): “The first involves the organization of the endosome membrane into specialized units highly enriched for a class of membrane proteins called tetraspanins [35].”
Tetraspanins: push and pull in suppressing and promoting metastasis (2009, background): “As recently reviewed, potential pathways whereby CD63 prohibits metastasis formation may rely on integrin endocytosis, lysosomal degradation of MMP14 and recruitment of TIMP1 (tissue inhibitor of metalloproteinase 1”
MiR-133b promotes neural plasticity and functional recovery after treatment of stroke with multipotent mesenchymal stromal cells in rats via transfer of exosome-enriched extracellular particles (2013, positive): “CD63 is a surface protein used as a common marker of exosomes [66].”
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells (2011, background): “The tetraspanin CD63 is very abundant in exosomes, and inside cells localizes mainly to MVBs and lysosomes, with only a small pool present at the plasma membran”