MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

By C. Welch, Y. Chen, R. Stallings. Oncogene, 2007

852 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Neurology

View Paper: https://www.semanticscholar.org/paper/f4562af816afa9a82808183c2f11f11375d72544

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In Cancer Research

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Citations in the corpus

miR-34 – a microRNA replacement therapy is headed to the clinic (2012, background): “, 2011), brain (Welch et al., 2007; Cole et al., 2008; Wei et al., 2008; Feinberg-Gorenshtein et al., 2009), cervix (Wang et al.”
MicroRNA and cancer (2012, background): “In accordance with a tumour-suppressive role, miR-34 members are downregulated in various cancers and the miR-34a locus located at 1q36 has been found lost in cases of neuroblastomas and in pancreatic cancer cell lines (Chang et al., 2007; Welch et al., 2007).”
The mammalian ovary from genesis to revelation. (2009, background): “Aside from ovarian cancer, reduced mir-34 expression has been reported in neuroblastoma (658), pancreatic cancer (653), and non-small cell lung cancer (652).”
MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “In addition, miR-34a resulted in an increase in caspase-dependent death when introduced into two cell lines (Welch et al., 2007) and contributed to an increase in p53-mediated apoptosis (Chang et al.”
microRNA as Biomarkers and Diagnostics (2016, background): “…especially AGO2, which has a high incidence of gene alterations across multiple cancer types (Huang et al., 2014). miRNAs can act as oncogenes or tumor suppressors, depending on the cellular context and the genes targeted (Esquela-Kerscher and Slack, 2006;Welch et al., 2007; Yu et al., 2010).”
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. (2007, background): “It has also very recently been reported that reduced miR-34a expression associated with loss of 1p36 is a frequent event in neuroblastoma (Welch et al., 2007).”
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis. (2014, methodology): “3 ′ UTRs of human and mouse IL6R were PCR amplified from oligo-dT–primed cDNA of human diploid fibroblasts with the Verso cDNA kit (Thermo Scientific), inserted into pGL3-control-MCS (62), and verified by sequencing.”
MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells (2009, positive): “Our data are consistent with the reported tumor suppressor function of miR-34 [6,8,9,11,22].”