Lessons from the past and charting the future of marine natural products drug discovery and chemical biology

By W. Gerwick, B. Moore. Chemistry and Biology, 2012

602 citations recorded by the source corpus.

Summary Marine life forms are an important source of structurally-diverse and biologically-active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. These success stories have had to overcome difficulties inherent to natural products-derived drugs, such as adequate sourcing of the agent and issues related to structural complexity. Nevertheless, several marine-derived agents are now approved, most as `first-in-class' drugs, with 5 of 7 appearing in the past few years. Additionally, there is a rich pipeline of clinical and pre-clinical marine compounds to suggest their continued application in human medicine. Understanding of how these agents are biosynthetically assembled has accelerated in recent years, especially through interdisciplinary approaches, and innovative manipulations and re-engineering of some of these gene clusters are yielding novel agents of enhanced pharmaceutical properties compared with the natural product.

Subfields: Biotechnology, Cancer Research, Pharmacology

View Paper: https://www.semanticscholar.org/paper/664e67eee9252f7c913cd9247ad7b9c5b1444bab

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

  1. D. Newman
  2. G. Cragg

In Pharmacology

  1. G. Cragg
  2. D. Newman
  3. A. Harvey
  4. M. Gordaliza

Citations in the corpus