CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.

By Vyara Valkanova, C. Allan. Journal of Affective Disorders, 2013

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Depression sum-scores don’t add up: why analyzing specific depression symptoms is essential (2015, background): “Moving away from genes and gene expression to hormones, the hypothesis that depression can be caused by inflammation has received considerable attention in recent years [23,24].”
Inflammation: depression fans the flames and feasts on the heat. (2015, background): “Supporting a causal pathway, higher IL-6 and CRP predicted the subsequent developmentofdepressivesymptoms(6).”
Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder (2015, background): “Gender (female/male) Age (cases/controls) Depression diagnosis and severity scale Country Quality score Basterzi AD et al., 2005 1 Outpatients IL-6 46 (23/23) 40/6 33.8 ± 12.8 / 33.6 ± 12.5 DSM-IV, HAM-D Turkey 5 Carvalho LA et al., 2013 2 Inpatients IL-6, IL-10, IL-4, MCP-1 40 (19/21) 28/12 49.05 ±”