The CA1 Region of the Human Hippocampus Is a Hot Spot in Alzheimer's Disease
By Mark J. West, C. Kawas, L. Martin, Juan C. Troncoso. Annals of the New York Academy of Sciences, 2000
1,620 citations recorded by the source corpus.
Abstract: Data from an ongoing study of differences in the total number of neurons in the five major subdivisions of the hippocampal regions of the brains of patients with Alzheimer's disease (AD) and normal age‐matched controls confirm an earlier finding from our laboratories of a pronounced loss of CA1 neurons associated with AD. In view of an earlier finding that the CA1 region does not suffer normal age‐related neuronal loss, these data support the earlier conclusion that the neuropathologic mechanisms involved in the AD‐related losses in CA1 are not related to normal aging and that the study of the cellular and molecular events involved in the AD‐related loss of CA1 cells can aid in the identification of the unique pathologic processes associated with AD.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Physiology
View Paper: https://www.semanticscholar.org/paper/f3e94f3b69167ce3d6c3613b052261210d250d66
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- Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity (2016, neutral): “humans (West et al., 2006), DG alterations have also been”
- Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice (2011, positive): “We chose this site for the injection according to previous studies that described large number of NFTs and extensive neuron loss from the CA1 region of the hippocampus in patients with AD in comparison with age-matched controls [32-35].”