Biomolecular coronas provide the biological identity of nanosized materials.

By M. Monopoli, Christoffer Åberg, Anna Salvati, K. Dawson. Nature Nanotechnology, 2012

1,025 citations recorded by the source corpus.

The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future.

Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/f3e018cc26e36b4af92789494dbe02721f6b9ce9

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Citations in the corpus

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery (2015, positive): “The corona formation non-specifically facilitates uptake of NPs by cells encountered during their circulation, including endothelial cells [21, 22], similar to the opsonin-dependent MPS cell uptake.”
In vitro approaches to assess the hazard of nanomaterials (2017, background): “…accepted protein corona paradigm (Lundqvist et al., 2008; Cedervall et al., 2007) in the nanotoxicology also has to be considered (Wan et al., 2015; Monopoli et al., 2012; Walczyk et al., 2010), since the protein corona formed on NM surface may significantly alter the NMs surface charge as seen by…”
Colloidal nanoparticles as advanced biological sensors (2014, background): “Through electrostatic interactions and hydrogen bonding, zwitterionic ligands can bind large numbers of water molecules that act to restrict nonspecific interactions with surrounding biomolecules (42, 43).”
Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers. (2016, background): “These results lead to fundamental insights that have to be considered for future nanocarrier design: (1) the stealth effect is not a polymer effect alone, but a secondary effect; (2) degradable poly(phosphoester)s are potential PEG alternatives; (3) the chemical structure of the stealth polymer can ”
Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. (2014, neutral): “[12,147].”
The role of lipid components in lipid nanoparticles for vaccines and gene therapy (2022, positive): “It may be that changes in the apparent pKa values endow distinct protein coronas [34,111] that could alter LNP fate.”
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. (2014, background): “designed to avoid it, a subset of these proteins will adsorb to its surface, forming a protein 'corona'.(20,21)”