Neocortical glial cell numbers in human brains.

By D. Pelvig, H. Pakkenberg, A. K. Stark, Bente Pakkenberg. Neurobiology of Aging, 2008

600 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/f3d54fd31756d3e9388d70b16fe165e49acf4bf4

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In Developmental Neuroscience

In Neurology

In Physiology

N. J. Allen

Citations in the corpus

The Human Brain in Numbers: A Linearly Scaled-up Primate Brain (2009, unknown): “In fact, although men have been reported to have more neurons in the cerebral cortex than women (Pakkenberg and Gundersen, 1997; Pelvig et al., 2008), there is no signifi cant correlation between brain size and general cognitive ability within families (Schoenemann et al.”
Microglia regulate the number of neural precursor cells in the developing cerebral cortex (2013, background): “The human cerebral cortex is populated by 20 –25 billion neurons (Pelvig et al., 2008) that are generated in the ventricular zone (VZ) and subventricular zone (SVZ) during prenatal development (Rakic, 2009; Lui et al., 2011).”
Imaging brain microstructure with diffusion MRI: practicality and applications (2019, background): “In adult human neocortex, [47, 48] find the proportion of glial cells (by cell count) to be 76.”
The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain (2018, background): “In the forebrain, neuron and astrocyte cell numbers do not significantly change with age, demonstrating that changes in performance are due to altered properties of these cells rather than cell death (Pelvig et al., 2008; Samson and Barnes, 2013).”
The impact of aging and gender on brain viscoelasticity (2009, unknown): “This hypothesis is supported by reports of a decreasing neuron–glia ratio in healthily aging brains (Terry et al., 1987) and, consistent with the sex disparity observed by MRE, a higher neuron–glia ratio in women than in men (Pelvig et al., 2007).”
Physiology of Astroglia. (2018, unknown): “On the basis of morphological criteria, in the neocortex astrocytes accounted for ~20 40%, oligodendrocytes for 50 75% and microglia for 5 10% of the total glial population (197, 1361).”
Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled‐up primate brain (2009, methodology): “…are available only for some structures, such as the cerebral cortex (von Economo and Koskinas, 1925; Shariff, 1953; Pakkenberg, 1966; Pakkenberg and Gundersen, 1997; Pelvig et al., 2008), cerebellum (Lange, 1975; Andersen et al., 1992), and some subcortical nuclei (Pakkenberg and Gundersen, 1988).”
The Search for True Numbers of Neurons and Glial Cells in the Human Brain: A Review of 150 Years of Cell Counting (2016, background): “On the high end, the group of B. Pakkenberg reported 20– 32 billion neurons (Pakkenberg et al., 1989; Braendgaard et al., 1990; Pakkenberg, 1992, 1993; Pakkenberg and Gundersen, 1997; Pelvig et al., 2003, 2008).”