Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
By R. Huxley, A. Ansary-Moghaddam, A. B. D. González, F. Barzi, M. Woodward. British Journal of Cancer, 2005
1,127 citations recorded by the source corpus.
Pancreatic cancer is the eighth major form of cancer-related death worldwide, causing 227 000 deaths annually. Type-II diabetes is widely considered to be associated with pancreatic cancer, but whether this represents a causal or consequential association is unclear. We conducted a meta-analysis to examine this association. A computer-based literature search from 1966 to 2005 yielded 17 case–control and 19 cohort or nested case–control studies with information on 9220 individuals with pancreatic cancer. The age and sex-adjusted odds ratio (OR) for pancreatic cancer associated with type-II diabetes was obtained from each study. The combined summary odds ratio was 1.82 (95% confidence interval (95% CI) 1.66–1.89), with evidence of heterogeneity across the studies (P=0.002 for case–control and P=0.05 for cohort studies) that was explained, in part, by higher risks being reported by smaller studies and studies that reported before 2000. Individuals in whom diabetes had only recently been diagnosed (<4 years) had a 50% greater risk of the malignancy compared with individuals who had diabetes for ⩾5 years (OR 2.1 vs 1.5; P=0.005). These results support a modest causal association between type-II diabetes and pancreatic cancer.
Subfields: Epidemiology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/f2fb01465f6a062adcff912fa65f4d39e377326b
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Citations in the corpus
- Glycemic index, glycemic load, and chronic disease risk--a meta-analysis of observational studies. (2008, background): “Larsson et al (55) reported a 30% increase in risk of colorectal cancer in a metaanalyses of persons with type 2 diabetes; similarly, Huxley et al (56) found an 82% increase in risk of pancreatic cancer.”
- Obesity and Cancer: The Role of Dysfunctional Adipose Tissue (2009, background): “In addition, diabetes mellitus, a disease characterized by insulin resistance, is associated with an increased risk of breast, colorectal, pancreatic, and bladder cancer (58-61).”
- Recent progress in pancreatic cancer (2013, background): “96) increased risk of pancreatic cancer compared with nondiabetics.(5) In addition, new-onset diabetes can be the first sign of pancreatic cancer.”
- Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors (2019, background): “5- to 2-fold higher in type II diabetes even when impaired glucose tolerance is detected more than 5 years [131] or 10 years before the onset of cancer [132].”