Molecular mechanisms that confer antibacterial drug resistance

By C. Walsh. Nature, 2000

1,530 citations recorded by the source corpus.

Subfields: Molecular Biology, Molecular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/f2f4afb2ee1ce3b7b878995e22a7e182b1097083

How researchers see this paper

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In Molecular Biology

1. Riccardo Zecchina
2. Johannes Berg
3. H. C. Nguyen
4. F. Codjoe
5. Terence Hwa
6. E. Donkor
7. Christopher K. Yost
8. Eric Haag

In Molecular Medicine

1. F. Codjoe
2. C. Bouki
3. E. Diamadopoulos
4. G. Perron
5. E. Donkor
6. Christopher K. Yost
7. Eric Haag
8. Nathan D. Price

In Pharmacology

1. F. Codjoe
2. E. Donkor
3. Christopher K. Yost
4. Eric Haag
5. Nathan D. Price
6. Sriram Chandrasekaran
7. J. True
8. Y. Kwon

Citations in the corpus

• Growth-rate dependent global effects on gene expression in bacteria (2009, background): “The abrupt increase of the growth rate, and thus of bacterial fitness, in the bistable region may provide a driving force promoting the rapid evolution of antibiotic resistance (Walsh, 2000) without the need for elaborate regulation.”
• Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics (2014, background): “It is now clear that well-studied mechanisms involved in classical antibiotic resistance, such as efflux or antibiotic-modifying enzymes, play only a marginal role in the ability of biofilms to survive antibiotics (20, 21).”
• Carbapenem Resistance: A Review (2017, background): “These mechanisms have been recognised in other organisms such as Enterobacter aerogenes and Klebsiella species against imipenem agent [42].”
• Probabilistic integrative modeling of genome-scale metabolic and regulatory networks in Escherichia coli and Mycobacterium tuberculosis (2010, background): “It could also serve as a potential drug target, as most drugs target membrane biosynthesis in microbes (37).”
• Developmental system drift and flexibility in evolutionary trajectories (2001, background): “Studies of antibiotic resistance mechanisms in bacteria indicate that there is often more than one type of genetic alteration that bacteria have deployed against each of seven classes of chemical antibiotics, but these appear to be quite finite and have occurred repeatedly in different species (Baqu”