Early coagulopathy predicts mortality in trauma.
By J. Macleod, M. Lynn, M. Mckenney, S. Cohn, M. Murtha. Journal of Trauma, 2003
1,220 citations recorded by the source corpus.
Subfields: Critical Care and Intensive Care Medicine, Emergency Medicine, Surgery
View Paper: https://www.semanticscholar.org/paper/f2b0669e5dbe283b46fa2d16effba679fcd12632
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Citations in the corpus
- Management of bleeding following major trauma: an updated European guideline (2010, background): “Rationale Major trauma results not only in bleeding from anatomical sites but also frequently in coagulopathy, which is associated with a several-fold increase in mortality [3,5,8,9,245].”
- Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway? (2007, background): “Two recent studies have identified an acute coagulopathy that is present on arrival in the emergency department in approximately one quarter of major trauma patients.(7,8) Patients arriving with a coagulopathy were 4 times more likely to die than those with normal coagulation.”
- Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations. (2006, background): “The presence of an abnormal prothrombin time (PT) on admission is associated with a tripling of the mortality rate of injured patients, and this mortality tends to occur early.(30) Irreversible bleeding due to the coagulopathy of trauma causes the largest proportion of post-operative trauma fataliti”
- Inflammation and coagulation (2010, background): “5 in critically ill patients was found to predict excessive bleeding and increased mortality (32, 33).”
- The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition (2019, background): “These patients develop multiple organ failure and experience death more frequently than patients with similar injury patterns in the absence of coagulopathy [11, 13, 14, 18, 19].”
- The coagulopathy of trauma: a review of mechanisms. (2008, background): “Clinically, injury severity is closely associated with the degree of coagulopathy.(12,13) However, patients with severe tissue injury but no physiologic derangement rarely present with a coagulopathy and have a relatively low mortality rate.”
- Management of bleeding and coagulopathy following major trauma: an updated European guideline (2013, background): “About one-third of all bleeding trauma patients present with a coagulopathy upon hospital admission [4-7].”
- Handbook of Big Data (2016, background): “…shapes can completely fill their cells to represent extremal correlations as these are geometrically similar to the shapes of the containing cells (at least if the the default aspect ratio of the blockplot is maintained), whereas all other shapes leave residual space even when maximally expanded.”
- The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “bleeding-induced shock, tissue injury-related thrombin-thrombomodulin-complex generation 25 and the activation of anticoagulant and fibrinolytic pathways (Figure 1) [9-11, 14, 18-23].”
- Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients (2008, background): “In 2003, Brohi et al and MacCloud et al separately described the early coagulopathy of trauma that is present on admission to the emergency department (ED) in 25% of patients and associated with increased mortality.(21,22) With this new information in mind, clinicians treating combat injuries in Ira”