Increased Plasma and Platelet to Red Blood Cell Ratios Improves Outcome in 466 Massively Transfused Civilian Trauma Patients
By J. Holcomb, C. Wade, J. Michalek, G. Chisholm, L. Zarzabal, M. Schreiber, E. Gonzalez, G. Pomper, J. Perkins, P. Spinella and 2 more. Annals of Surgery, 2008
1,089 citations recorded by the source corpus.
Subfields: Biochemistry, Critical Care and Intensive Care Medicine, Emergency Medicine
View Paper: https://www.semanticscholar.org/paper/a94bf6d31532abe2284d6e7622b8b42024158b6c
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In Critical Care and Intensive Care Medicine
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Citations in the corpus
- The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “Although 17 most of the combat [460, 461] and civilian studies [462-466], one meta-analysis (34) and one 18 systematic review [467, 468] that investigated the impact of platelet transfusion in severe 19 trauma and massive transfusion showed an improved survival rate among patients receiving 20 high ”
- The Prospective, Observational, Multicenter, Major Trauma Transfusion (PROMMTT) Study: Comparative Effectiveness of a Time-varying Treatment with Competing Risks (2013, neutral): “Hemorrhage 7 (88) 46 (84) 24 (75) 9 (43) 3 (19) 3 (14) 3 (4) 0 Brain injury 0 9 (16) 10 (31) 10 (48) 10 (63) 13 (62) 32 (48) 1 (17) Airway/respiratory 1 (13) 2 (4) 3 (9) 2 (10) 1 (6) 2 (10) 15 (22) 3 (50) Sepsis 0 0 0 0 0 1 (5) 6 (9) 2 (33) Multiple organ failure 0 0 0 0 0 2 (10) 24 (36) 5 (83) Card”
- Management of bleeding and coagulopathy following major trauma: an updated European guideline (2013, background): “Although decreased morbidity due to aggressive use of plasma and platelets has been reported [318,349,354], routine early prophylactic platelet transfusion as part of a massive transfusion protocol appears unjustified at this time”
- Management of bleeding following major trauma: an updated European guideline (2010, methodology): “Seven studies showed better outcomes using a high FFP:RBC ratio [3,261-266] and two did not [250,267].”