The Importance of β-Cell Failure in the Development and Progression of Type 2 Diabetes

By S. Kahn. 2001

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Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. (2004, background): “Rather, the ability of the pancreas to maintain its high insulin secretory rate declines (1, 2, 9, 11, 13, 15, 16, 18, 19), leading to a worsening of glucose intolerance and eventual development of overt T2DM.”
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes (2003, background): “Many groups have suggested that insulin resistance is the primary abnormality and that beta-cell dysfunction is a late event that arises from the prolonged, increased secretory demand placed on the beta cell by insulin resistance [2, 3]. In contrast, others have suggested that reduced beta-cell func”