Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.

By M. George, T. E. Abraham. Journal of Controlled Release, 2006

1,955 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/f2733f79287bd46505ccfc9bed16d0c77e110d56

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In Molecular Medicine

1. David J. Mooney
2. K. Lee
3. M. Cook
4. G. Tzortzis
5. N. Bhattarai
6. J. Gunn
7. Miqin Zhang
8. D. Charalampopoulos

In Pharmaceutical Science

1. V. Khutoryanskiy

Citations in the corpus

• An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery (2017, background): “Chitosan is an excellent carrier for such drugs as it is mucoadhesive, permeation enhancer and forms a protective barrier for the drug [71].”
• Preparation and Characterization of Films Based on Alginate and Aloe Vera (2011, background): “hyperborea, Ascophyllum nodosum, and Macrocystis pyrifera.([1,7]) From a structural point of view, alginates contains two acid units, b-(1-4)-linked D-mannuronic acid (M) and a-(1-4) linked L-guluronic acid (G), conjugated in the form of homopolymeric (MM or GG) and heteropolymeric blocks (MG or GM)”
• Chitosan-based hydrogels for controlled, localized drug delivery. (2010, background): “insulin (effective against diabetes mellitus) showed selective release in the intestine [172].”
• Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications. (2007, background): “The adhesive properties of chitosan in a swollen state have been shown to persist well during repeated contacts of chitosan and the substrate [128] which implies that, in addition to the adhesion by hydration, many other mechanisms, such as hydrogen bonding and ionic interactions might also have be ”
• Microencapsulation of probiotics for gastrointestinal delivery. (2012, background): “In pharmaceutical applications, the coating of alginate microspheres with chitosan leads to the ‘controlled’ (as opposed to ‘burst’) release of entrapped drugs in simulated intestinal conditions [102].”