Enhancement of Hippocampal Neurogenesis by Lithium

By Guang Chen, G. Rajkowska, F. Du, N. Seraji‐Bozorgzad, Husseini K. Manji. Journal of Neurochemistry, 2000

641 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

The current state of the neurogenic theory of depression and anxiety. (2015, background): “In 2000, three of the most effective treatments of affective disorders in humans – electroconvulsive shock [47,48], fluoxetine (the prototypic SSRI) [5], and lithium [49] – were shown to boost AHN.”
Adult neurogenesis: from precursors to network and physiology. (2005, background): “Interestingly, the expression of bcl-2, an antiapoptotic regulator, is also increased suggesting that survival of the newly born neurons might be enhanced (84).”
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus (2005, background): “Several different types of antidepressants, including tricyclic antidepressants, serotonin selective reuptake inhibitors, and also lithium increase neuronal proliferation in the dentate gyrus when administered chronically (Chen et al., 2000; Malberg et al., 2000).”
Interaction between BDNF and Serotonin: Role in Mood Disorders (2008, background): “Importantly, antidepressants and the mood stabilizer lithium have been shown to elicit an increase in hippocampal neurogenesis (”
The cellular neurobiology of depression (2001, background): “, and lithium also enhances hippocampal neurogenesis in the adult roden”