Protein phosphorylation in signaling--50 years and counting.

By Tony Pawson, John D. Scott. TIBS -Trends in Biochemical Sciences. Regular ed, 2005

663 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f241170b62e6fefed8d9afab31d645fc649b1414

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In Molecular Biology

Citations in the corpus

ELM—the database of eukaryotic linear motifs (2011, background): “The functionality of linear motifs can be modulated by modifications such as phosphorylation (23,24).”
Evolutionary and Physiological Importance of Hub Proteins (2006, neutral): “Phosphorylation often dictates regulation through protein interactions and/or protein degradation by the ubiquitin-proteasome system [34,35].”
Post-translational modifications in proteins: resources, tools and prediction methods (2021, background): “However, it took another 20 years before Eugene Kennedy described the first enzymatic phosphorylation of proteins (43).”
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease (2007, background): “jpg" NDATA ITEM> ]> Protein phosphorylation is a key cellular signalling mechanism that induces changes in protein conformatio”
Drugs for allosteric sites on receptors. (2014, methodology): “An mGlu5 PAM, VU0092273 (23), is optimized into a highly selective and potent mGlu3 NAM, VU0469942 (25).”
An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets (2005, background): “Furthermore, protein phosphorylation levels are central to our current understanding of cell division and signal transduction pathways in both normal and diseased cell state”
High-throughput screening assays for the identification of chemical probes. (2007, background): “Protein kinases mediate the most prevalent post-translational modification in cells, phosphorylate an array of targets in signaling cascades and cycles, and are important for therapeutic intervention, particularly oncolog”
A probability-based approach for high-throughput protein phosphorylation analysis and site localization (2006, background): “In addition to precision and sensitivity within large-scale phosphorylation data sets, proper phosphorylation site location is also critical because many biological processes are regulated through the phosphorylation of specific residue”