ELM—the database of eukaryotic linear motifs
By Holger Dinkel, S. Michael, Robert J. Weatheritt, Norman E. Davey, K. Roey, B. Altenberg, Grischa Toedt, B. Uyar, Markus Seiler, Aidan Budd and 19 more. Nucleic Acids Res., 2011
348 citations recorded by the source corpus.
Linear motifs are short, evolutionarily plastic components of regulatory proteins and provide low-affinity interaction interfaces. These compact modules play central roles in mediating every aspect of the regulatory functionality of the cell. They are particularly prominent in mediating cell signaling, controlling protein turnover and directing protein localization. Given their importance, our understanding of motifs is surprisingly limited, largely as a result of the difficulty of discovery, both experimentally and computationally. The Eukaryotic Linear Motif (ELM) resource at http://elm.eu.org provides the biological community with a comprehensive database of known experimentally validated motifs, and an exploratory tool to discover putative linear motifs in user-submitted protein sequences. The current update of the ELM database comprises 1800 annotated motif instances representing 170 distinct functional classes, including approximately 500 novel instances and 24 novel classes. Several older motif class entries have been also revisited, improving annotation and adding novel instances. Furthermore, addition of full-text search capabilities, an enhanced interface and simplified batch download has improved the overall accessibility of the ELM data. The motif discovery portion of the ELM resource has added conservation, and structural attributes have been incorporated to aid users to discriminate biologically relevant motifs from stochastically occurring non-functional instances.
Subfields: Molecular Biology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/6e6eecc13a594edbb3392819026f5d8a23818536
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In Molecular Biology
- Francesca Diella
- Roberto Mosca
- Arnaud Céol
- Toby J. Gibson
- Amelie Stein
- Roger Olivella
- Aidan Budd
- Patrick Aloy
In Pharmacology
Citations in the corpus
- The eukaryotic linear motif resource ELM: 10 years and counting (2013, methodology): “The ELM resource has been updated significantly since the last release (20), with 26 new ELM classes and 689 new ELM instances, raising the total count to 197 ELM classes and 2404 ELM instances (Tables 1 and 2).”
- ELM 2016—data update and new functionality of the eukaryotic linear motif resource (2015, background): “More than 10 years since its inception (7,8) it remains a popular resource being continually used by scientists worldwide.”
- 3did: a catalog of domain-based interactions of known three-dimensional structure (2013, background): “However, the short motifs are harder to detect automatically than evolutionary conserved domain fingerprints, therefore many resources of domain–motif interactions, such as ELM (30), rely on manual curation.”