Functions of cell surface heparan sulfate proteoglycans.

By M. Bernfield, M. Götte, P. Park, O. Reizes, M. L. Fitzgerald, J. Lincecum, M. Zako. 1999

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. Xinhua Lin
2. Kathryn A. Porter
3. Dima Kozakov
4. Sandor Vajda
5. S. Sarrazin
6. David R. Hall
7. Bing Xia
8. J. Esko

Citations in the corpus

• The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis (2022, neutral): “The generated cells were denoted EXTL3ΔN CRISPREXT1 cells and EXTL3ΔN CRISPRcontrol cells, respectively.”
• Posttranslational Protein Modification in Archaea (2005, background): “In fitting with a role for the sulfated S-layer glycoprotein oligosaccharide chains in maintaining the rod shape of Halobacterium salinarum cells, it was noted that similarities exist in the overall structures of the S-layer glycoprotein and proteoglycans, components of the extracellular matrix of a”
• The Structure of Glycosaminoglycans and their Interactions with Proteins (2008, background): “Thus, HSPGs are formed both on the cell surface and in ECMs.”
• The sweet and sour of cancer: glycans as novel therapeutic targets (2005, unknown): “fcgi?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3576">IL-8 )”
• Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “Cellular surfaces are dominated by negatively charged sulphated proteoglycans moleculs that play pivotal roles in cellular proliferation, migration, and motility [23-24].”
• The Cysteine-Rich Domain of Human Adam 12 Supports Cell Adhesion through Syndecans and Triggers Signaling Events That Lead to β1 Integrin–Dependent Cell Spreading (2000, background): “…biological processes by virtue of the binding of their glycosaminoglycans to growth factors, extracellular matrix proteins, cell adhesion molecules, and proteases and protease inhibitors (Carey, 1997; Rapraeger and Ott, 1998; Woods et al., 1998; Bernfield et al., 1999; Zimmermann and David, 1999).”
• Matrix metalloproteinases as modulators of inflammation. (2008, background): “The in vivo substrate(s) mediating these effects are unknown, but possible mechanisms include MMP-mediated proteolysis of cell surface proteoglycans that bind and regulate chemokines gradients [48,54].”
• Proteoglycan form and function: A comprehensive nomenclature of proteoglycans (2015, background): “The eponym syndecan was coined by the late Merton Bernfield [29] to define a class of transmembrane proteoglycans that would connect (from the Greek syndein, “bind together”) the surface of the cells to the underlying extracellular matrix.”