Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
By R. Iozzo, L. Schaefer. Matrix Biology, 2015
1,055 citations recorded by the source corpus.
We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores. These three signatures were utilized to design four major classes of proteoglycans with distinct forms and functions: the intracellular, cell-surface, pericellular and extracellular proteoglycans. The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants. The biological functions of these four proteoglycan families are critically assessed in development, cancer and angiogenesis, and in various acquired and genetic diseases where their expression is aberrant.
Subfields: Cell Biology, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/2bdeb24187c799c0d705825bf21a1ed57db355ff
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Citations in the corpus
- Extracellular matrix structure. (2016, background): “PGs and GAGs play important roles in normal physiology and development of various diseases since their biosynthesis is markedly modified during ECM remodeling in all pathologies [14, 16-19].”
- Role of Extracellular Matrix in Development and Cancer Progression (2018, background): “Several groups of synthetic MMP inhibitors, such as Marimastat, Minocycline, and Matimastat, have been developed to target broad groups of MMPs and tested in stage III clinical trials in late stage cancer patients [183].”
- Determinants of Glycosaminoglycan (GAG) Structure (2015, background): “More than 40 different protein cores have been identified, many of which have been grouped according to their protein domains [8].”