Lipofuscin: mechanisms of age-related accumulation and influence on cell function.

By U. Brunk, A. Terman. Free Radical Biology & Medicine, 2002

943 citations recorded by the source corpus.

Subfields: Epidemiology, Physiology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/f1b39de9424e4a91a11fc8898167ba48c2fd8469

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In Physiology

1. Karine Clément

Citations in the corpus

• Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. (2005, background): “On transmission electron microscopy, macrophage projections frequently held adipocyte membranes that contained cytoplasm lipofuscin inclusions, a typical feature of stressed, aged, and useless cells (36,37).”
• Autophagy is a Protective Mechanism in Normal Cartilage and its Aging-related Loss is Linked with Cell Death and Osteoarthritis (2010, background): “The mechanisms by which autophagy is lost with aging are mainly related to the failure of the lysosomal hydrolases, resulting in an increase of toxic protein products and slow clearance of autophagosomes in the aging tissues (40).”