Molecular Modes of Action of Defensive Secondary Metabolites

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Modes of Action of Herbal Medicines and Plant Secondary Metabolites (2015, background): “We have speculated that their shape had been formed during evolution and selection by a process of “evolutionary molecular modeling” [51,52,54] in analogy to chemical molecular modeling in medicinal chemistry.”
Evolution of secondary metabolites in legumes (Fabaceae) (2013, unknown): “Pyrrolizidinealkaloidsbecomeactivatedintheliverofherbivores; they then alkylate DNA which leads to mutations and even cancer in animals and humans (reviewed in McLean, 1970; Hartmann and Witte, 1995; Wink and Schimmer, 2010).”
Chemical composition and antifungal effects of three species of Satureja (S. hortensis, S. spicigera, and S. khuzistanica) essential oils on the main pathogens of strawberry fruit (2015, background): “Other mechanisms include affecting the functional integrity of mitochondria, inhibiting the synthesis of ATP in the mitochondria of fungi strains and accumulation of ROS after using essential oils that this phenomenon is considered as one of the primary biochemical hall marks of apoptosis promoting ”
Boosting Immune Function and Disease Bio-Control Through Environment-Friendly and Sustainable Approaches in Finfish Aquaculture: Herbal Therapy Scenarios (2020, background): “2004; Teuscher and Lindequist 2010), which prevents cell division and immune-modulation (Kuljanabhagavad and Wink 2009; Wink and Schimmer 2010; Su et al. 2015a, 2015b).”