The pathogenic basis of malaria

By L. Miller, D. Baruch, K. Marsh, O. Doumbo. Nature, 2002

1,883 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Innate immunity to malaria (2004, background): “The rupture of erythrocytic schizonts is typically accompanied by bouts of fever, nausea, headaches and other symptoms of a systemic pro-inflammatory cytokine response, much of which is now believed to derive from cells of the innate immune syste”
Refractive index maps and membrane dynamics of human red blood cells parasitized by Plasmodium falciparum (2008, background): “Two major mechanical modifications are loss of RBC deformability (4–6) and increased cytoadherence of the invaded RBC membrane to vascular endothelium and other RBCs (7).”
Mechanisms of cell protection by heme oxygenase-1. (2010, background): “Plasmodium infection can also lead to the development of noncerebral forms of severe malaria that contribute significantly to the overall mortality associated with this infectious disease in humans (164, 165).”
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria. (2005, background): “Such changes in mechanical response are also known to play key roles in pathogenesis and pathophysiology [2,6,7].”