The Origins of Genome Complexity

By Michael Lynch, J. Conery. Science, 2003

1,630 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/f08753c7964863571b35ad786c50e81dea8f0bd5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Adrian W. R. Serohijos
2. Eugene V. Koonin
3. T. Ryan Gregory
4. O. De Clerck
5. Ajna S. Rivera
6. S. Barrett
7. J. C. Thrash
8. Jeanne M. Serb

In Molecular Biology

1. Eugene V. Koonin
2. T. Ryan Gregory
3. Laura A. Katz
4. W. Foissner
5. O. De Clerck
6. Ajna S. Rivera
7. S. Barrett
8. J. C. Thrash

In Plant Science

1. T. Ryan Gregory
2. O. De Clerck
3. S. Barrett
4. Todd H. Oakley
5. Kenneth H. Wolfe
6. J. Lennon
7. Eugene V. Koonin
8. Eugene I. Shakhnovich

Citations in the corpus

• Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics (2014, background): “Additionally, assuming that all other things are equal, vertebrates (with effective population sizes of 10 4 – 10 5 [46]) are predicted by Eqn.”
• The evolutionary dynamics of eukaryotic gene order (2004, background): “One possibility is that organisms with a large EFFECTIVE POPULATION SIZE (which we assume yeast must have) should be able to resist the spread of weakly deleterious mutations and therefore are expected to be more 'optimally' organize”
• Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote (2006, neutral): “The presence of a preferred subset in T. thermophila is likely a reflection of a large effective population size due to its free-living, sexually reproducing lifestyle (see [66,67] for additional discussion on the large population size of this species).”
• Synergy between sequence and size in Large-scale genomics (2005, background): “As more genome sequences are completed, it is becoming clear that genome size and total transposable-element content are strongly correlate”
• Genomic Consequences of Outcrossing and Selfing in Plants (2008, background): “1C), with important consequences for evolution at the genome level (Lynch and Conery 2003).”
• Diversity and geographic distribution of ciliates (Protista: Ciliophora) (2008, background): “…population sizes are large and relatively stable over time, then one might expect ciliate populations to contain high levels of neutral variation as has been argued for Tetrahymena thermophila (Gerber et al. 2002; Lynch and Conery 2003) and for several species of Paramecium (Snoke et al. 2006).”