Merging molecular mechanism and evolution: theory and computation at the interface of biophysics and evolutionary population genetics
By Adrian W. R. Serohijos, Eugene I. Shakhnovich. 2014
82 citations recorded by the source corpus.
The variation among sequences and structures in nature is both determined by physical laws and by evolutionary history. However, these two factors are traditionally investigated by disciplines with different emphasis and philosophy—molecular biophysics on one hand and evolutionary population genetics in another. Here, we review recent theoretical and computational approaches that address the critical need to integrate these two disciplines. We first articulate the elements of these integrated approaches. Then, we survey their contribution to our mechanistic understanding of molecular evolution, the polymorphisms in coding region, the distribution of fitness effects (DFE) of mutations, the observed folding stability of proteins in nature, and the distribution of protein folds in genomes.
Subfields: Genetics, Molecular Biology
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Genetics
- Martin Weigt
- Matteo Figliuzzi
- Alexander Schug
- H. Szurmant
- José N. Onuchic
- Anne-Florence Bitbol
- Faruck Morcos
- Herbert Levine
In Molecular Biology
- Martin Weigt
- Matteo Figliuzzi
- Alexander Schug
- H. Jacquier
- O. Tenaillon
- Anne-Florence Bitbol
- H. Szurmant
- José N. Onuchic
Citations in the corpus
- Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 (2015, background): “Critically important residues tend to be conserved, while unfavorable residues are observed less frequently.”