Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression.

By Wayne C. Drevets. Progress in Brain Research, 2000

675 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Cognitive Neuroscience, Psychiatry and Mental health

View Paper: https://www.semanticscholar.org/paper/f01acdd56a1d982ee9925fbad2bb1cf5b6c5b552

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Citations in the corpus

The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “Pathological changes associated with MDD have also been reported in the amygdala and prefrontal cortex (Drevets, 2000, 2001).”
Structural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine (2004, background): “, 2002 ) , and the anterior cingulate is implicated in primary depression and induc - tion of sadness ( Drevets , 2000 ; Vogt et al .”
Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. (2005, background): “For example, depression is accompanied by decreases in hippocampal volume (Sheline et al., 1996) and alterations in prefrontal cortical and amygdalar blood flow (Drevets, 2000).”
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. (2011, methodology): “Consistent with this hypothesis, volume reductions in the hippocampus and other brain regions, as determined by magnetic resonance imaging, have been described in both PTSD (71) and major depression (72).”
Sleep and emotions: a focus on insomnia. (2010, background): “Neuroimaging studies in major depression have identified structural and functional brain abnormalities in those structures that are involved in the regulation of emotions, for example in the prefrontal cortex, and the amygdala.(10)”
Neuroimaging studies of mood disorders. (2000, methodology): “Computer simulations of posttreatment images find that actual (partial volume corrected) metabolism decreases to normative levels during effective treatment (Drevets 2000).”
The cingulum bundle: Anatomy, function, and dysfunction (2018, positive): “Indeed, neuroimaging studies have consistently found this same region to function abnormally in disorders such as major depression (Drevets, 2000), while hypermetabolism in the subgenual cingulate and prefrontal cortex may predict favourable responses to anterior cingulotomies in this disorder…”
The proactive brain: memory for predictions (2009, background): “mised in depression (Mayberg & Liotti 1999; Drevets 2000; Anand et al. 2005), and its integrity is improved”
Regulation of the Hypothalamic‐Pituitary‐Adrenocortical Stress Response (2016, neutral): “Glucocorticoids also have profound context-specific effects on cognition that are of relevance to neuropsychiatric disorders linked to stress, including PTSD and depression.”
Letter to Neuroscience INCREASED SOCIAL FEAR AND DECREASED FEAR OF OBJECTS IN MONKEYS WITH NEONATAL AMYGDALA LESIONS (2001, background): “Amygdala dysfunction has also been implicated in human disorders ranging from social anxiety (Birbaumer et al., 1998) to depression (Drevets, 2000) to autism (Bachevalier, 1994; Baron-Cohen et al., 2000; Bauman and Kemper, 1993).”
Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic (2007, background): “The areas most reproducibly found to be dysregulated in common emotional disorders are the prefrontal cortex (PFC) and subgenual cingulate cortex (Cg25), which seem to be involved in emotion experience and processing, as well as the subcortical hippocampus and amygdala, which are involved in emotion”