The overlap of amyotrophic lateral sclerosis and frontotemporal dementia

By C. lomen-Hoerth, T. Anderson, B. Miller. Neurology, 2002

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TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration (2009, background): “Interestingly, approximately 20% of patients with ALS also develop FTLD, and approximately 15% of FLTD patients also develop ALS (4, 5).”
Expanded GGGGCC hexanucleotide repeat in non-coding region of C9ORF72 causes chromosome 9p-linked frontotemporal dementia and amyotrophic lateral sclerosis (2011, positive): “Similarly, as many as half of FTD patients develop clinical symptoms of motor neuron dysfunction (Lomen-Hoerth et al., 2002).”
Cognition and anatomy in three variants of primary progressive aphasia (2004, background): “Longer clinical follow-up will determine whether the motor involvement in NFPA could predict an evolution to the FTLD-MND syndrome.(62)”
Pathology of Neurodegenerative Diseases. (2017, background): “The 3R tauopathies include Pick’s disease and some forms of FTDP-17T, whereas 3R/4R tauopathies include AD, CTE, tangle predominant dementia, Guam Parkinson dementia complex, and some forms of FTDP-17T (Mackenzie et al. 2010).”
A comprehensive review of amyotrophic lateral sclerosis (2015, methodology): “Genetic testing can be used to differentiate inherited versus sporadic ALS and also to rule out other diseases that clinically mimic ALS.[33,115,171] Hence, genetic testing enables researchers to categorize and conceptualize the disease and will aid in mapping the various genetic mechanisms of each ”