Expression and function of galectin‐3, a β‐galactoside‐binding protein in activated T lymphocytes

By H. Joo, P. Goedegebuure, N. Sadanaga, M. Nagoshi, W. Bernstorff, T. Eberlein. Journal of Leukocyte Biology, 2001

149 citations recorded by the source corpus.

A soluble beta‐galactoside‐binding lectin, galectin‐3 has been shown tobe involved in cell adhesion and activation of immune cells. Althoughgalectin‐3 is known to be expressed in various types of cells, it hasnot been shown whether galectin‐3 is expressed in T lymphocytes. Wepresent evidence here that galectin‐3 is expressed in activated murineT lymphocytes including CD4+ and CD8+ T cellsbut not in resting T cells. Galectin‐3 expression was induced byanti‐CD3 mAb or mitogen and enhanced by common γ‐chain signalingcytokines, IL‐2, IL‐4, and IL‐7, in activated T lymphocytes, whereasthe inflammatory cytokines including TNF‐α and IFN‐γ did not.Galectin‐3 expression and proliferation were down‐regulated bywithdrawal of IL‐2 and gamma irradiation. Anti‐sense but not sensephosphorothioated oligonucleotides for galectin‐3 inhibited galectin‐3expression and blocked proliferation of T cells significantly. Thisstudy suggests that up‐regulation of galectin‐3 plays an important rolein proliferation of activated T lymphocytes.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/eff289ab6881eb7d8cb1baa1082816ba20e350b2

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In Immunology

1. M. Toscano
2. Gabriel A. Rabinovich

Citations in the corpus

• Turning 'sweet' on immunity: galectin–glycan interactions in immune tolerance and inflammation (2009, background): “In support of this concept, the expression of galectin 1 and galectin 3 is upregulated in inflammatory macrophages and activated T cell”