Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins.

By D. Schaer, P. Buehler, A. Alayash, J. Belcher, G. Vercellotti. Blood, 2013

727 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Pediatrics, Perinatology and Child Health

View Paper: https://www.semanticscholar.org/paper/a53718b74b3298b35cb7ea2ea775b944a7800826

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

1. P. Everts
2. J. Belcher
3. K. Onishi
4. Chunsheng Chen
5. P. Jayaram
6. Ann Smith
7. R. Hebbel
8. K. Nath

Citations in the corpus

• Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. (2014, background): “Specifically, this study examined the hypothesis that heme, released from plasma Hb during hemolysis, is an extracellular cell-signaling molecule and a causal factor in the development of vascular inflammation and vaso-occlusion in SCD.”
• Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020 (2020, background): “As a consequence, the RBC cell membrane disintegrates and releases toxic hemoglobin (Hb), measured as plasma-free hemoglobin (PFH), hemin, and iron [75].”