NETWORK EXPLORATION VIA THE ADAPTIVE LASSO AND SCAD PENALTIES

By Jianqing Fan, Yang Feng, Yichao Wu. Annals of Applied Statistics, 2009

434 citations recorded by the source corpus.

Graphical models are frequently used to explore networks, such as genetic networks, among a set of variables. This is usually carried out via exploring the sparsity of the precision matrix of the variables under consideration. Penalized likelihood methods are often used in such explorations. Yet, positive-definiteness constraints of precision matrices make the optimization problem challenging. We introduce non-concave penalties and the adaptive LASSO penalty to attenuate the bias problem in the network estimation. Through the local linear approximation to the non-concave penalty functions, the problem of precision matrix estimation is recast as a sequence of penalized likelihood problems with a weighted L1 penalty and solved using the efficient algorithm of Friedman et al. (2008). Our estimation schemes are applied to two real datasets. Simulation experiments and asymptotic theory are used to justify our proposed methods.

Subfields: Genetics, Molecular Biology, Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/ef5d4979a2234857084099bf3894901c331c330f

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In Genetics

  1. Mohsen Pourahmadi
  2. Martin J. Wainwright
  3. Bruce A. Craig
  4. Anindya Bhadra
  5. Po-Ling Loh
  6. Clifford Lam
  7. Jianqing Fan
  8. Lucy Xia

In Molecular Biology

  1. Mohsen Pourahmadi
  2. Le Song
  3. Lucy Xia
  4. Jianqing Fan
  5. Martin J. Wainwright
  6. Clifford Lam
  7. Po-Ling Loh
  8. Bruce A. Craig

In Statistics and Probability

  1. Jianqing Fan
  2. Clifford Lam
  3. Martin J. Wainwright
  4. Mladen Kolar
  5. Po-Ling Loh
  6. Yang Feng
  7. Mohsen Pourahmadi
  8. Tommaso Cai

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