Gene expression regulation mediated through reversible m6A RNA methylation

By Ye Fu, D. Dominissini, G. Rechavi, Chuan He. Nature reviews genetics, 2014

1,738 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ef5661fcc902bbf642712baeeaf4ed118e800578

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In Molecular Biology

1. Chuan He
2. Hailing Shi
3. Hongjun Song
4. Guo-li Ming
5. Jianjun Chen
6. Huilin Huang
7. Hengyou Weng
8. Chao Xu

Citations in the corpus

• SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features (2016, background): “Moreover, it is well known that the m6A modification is reversible, dynamic and sometimes tissue- or conditionspecific (3,4,19).”
• DNA methylation on N6-adenine in C. elegans (2015, positive): “Both fungi and animals are known to undergo methylation of adenosine in mRNA, with 6mA influencing mRNA stability (Fu et al., 2014) and RNA splicing (Dominissini et al., 2012; Liu et al., 2015).”
• Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA (2016, background): “consisting of the proteins methyltransferase-like 3 (METTL3), METTL14, and Wilms tumor 1 associated protein (WTAP), the activity of which is opposed by two m(6)A demethylases, fat mass and obesity-associated protein (FTO) and AlkB homolog 5 (ALKBH5) (27, 30).”
• YTH Domain: A Family of N6-methyladenosine (m6A) Readers (2018, background): “Incorporation of the methyl moiety at the N(6) atom of adenosine renders the m(6)A–U pair energetically unfavorable [35], which may cause destruction of the stem loop where it resides and lead to further global conformational rearrangement of the RNA [8].”
• Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases (2016, positive): “Recent studies have intensely investigated howm6Amodification of RNA contributes to central events in biology (Fu et al., 2014; Liu and Pan, 2016; Meyer and Jaffrey, 2014).”
• FMRP Modulates Neural Differentiation through m6A-Dependent mRNA Nuclear Export (2019, background): “…Export during Neural Differentiation As previous analyses have suggested that FMRP may bind to consensus RNA methylation motifs (Ascano et al., 2012; Edupuganti et al., 2017; Fu et al., 2014), we considered that FMRP could serve as an m6A reader to bind and interpret m6A to regulate RNA function.”
• METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification (2017, background): “This modification was found on adenosines embedded in the consensus sequence G[G > A]m6AC[U > A > C] across the mRNA transcripts, especially near the stop codons (Fu et al., 2014).”