Antiviral signaling through pattern recognition receptors.

By Taro Kawai, Shizuo Akira. 2006

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In Immunology

Citations in the corpus

Highly efficient reprogramming to pluripotency and directed differentiation of human cells using synthetic modified mRNA (2010, background): “Cel It is known that exogenous single-stranded RNA (ssRNA) activates antiviral defenses in mammalian cells through interferonand NF-kB-dependent pathways (Diebold et al., 2004; Hornung et al., 2006; Kawai and Akira, 2007; Pichlmair et al., 2006; Uematsu and Akira, 2007).”
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β (2008, background): “The latter group of TLRs induces a potent type I interferon response that is critical for antiviral defens”
How dying cells alert the immune system to danger (2008, background): “Another possible exception to Janeway's model is certain viral infections, because all viral molecules are synthesized by the host and don't contain obvious features that distinguish them from host proteins (although it is now clear that there are molecular features of some viruses that are recogniz”
Roles of plant small RNAs in biotic stress responses. (2009, background): “Activated TLRs signal downstream innate immune responses, which, unlike RNA silencing, are not sequence specific (40).”
Interferons at age 50: past, current and future impact on biomedicine (2007, background): “bacterial lipopolysaccharides induce IFNs through TLR4 and also recruit TRIF; viral glycoproteins bind and activate dif ferent TLRs.”
The NLRP3 Inflammasome Mediates in vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA (2009, background): “Previous studies have demonstrated that TLR3, 7, 8, and 9 represent the subset of TLRs that recognize viral nucleic acids and mediate the induction of type-I IFN (Kawai and Akira, 2007; Koyama et al., 2007).”
Peroxisomes are signaling platforms for antiviral innate immunity (2010, unknown): “Indeed IRF3 is also involved in IFN expression induced by non-RLRs (Kawai and Akira, 2007).”