Flexible nets

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Comprehensive review of methods for prediction of intrinsic disorder and its molecular functions (2017, background): “2 disordered proteins and regions are crucial for numerous cellular functions including regulation of transcription, translation [7-10] and cell signaling [11-15].”
p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept (2016, background): “This property explains why intrinsic disorder is a common feature of hubs in protein–protein interaction networks [31] and why it is frequently found in signaling proteins [32].”
Global topological features of cancer proteins in the human interactome (2006, background): “Examples of such are microarray expression data (Ideker et al., 2002; Sohler et al., 2004; de Lichtenberg et al., 2005), gene ontology (Formstecher et al., 2005), structural information (Dunker et al., 2005) and domain composition (Riley et al., 2005; Wuchty and Almaas, 2005).”