The role of the gut microbiota in NAFLD
By C. Leung, L. Rivera, John B. Furness, P. Angus. Nature Reviews Gastroenterology &Hepatology, 2016
933 citations recorded by the source corpus.
NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut health. Animal studies in which the gut microbiota are manipulated, and observational studies in patients with NAFLD, have provided considerable evidence that dysbiosis contributes to the pathogenesis of NAFLD. Dysbiosis increases gut permeability to bacterial products and increases hepatic exposure to injurious substances that increase hepatic inflammation and fibrosis. Dysbiosis, combined with poor diet, also changes luminal metabolism of food substrates, such as increased production of certain short-chain fatty acids and alcohol, and depletion of choline. Changes to the microbiome can also cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury. Evidence also suggests that certain food components and lifestyle factors, which are known to influence the severity of NAFLD, do so at least in part by changing the gut microbiota. Improved methods of analysis of the gut microbiome, and greater understanding of interactions between dysbiosis, diet, environmental factors and their effects on the gut–liver axis should improve the treatment of this common liver disease and its associated disorders.
Subfields: Epidemiology, Molecular Biology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/eef53a90aecbe64892d6d2ad16225b7746d05db9
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
In Molecular Biology
Citations in the corpus
- Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “Thus, its suppression is associated with a higher accumulation of lipids in the liver [87].”
- Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease (2018, background): “Furthermore, SCFA ameliorates gut barrier function, reducing the permeability of bacterial toxins and metabolic endotoxemia that can induce inflammation and insulin resistance [83].”