Abstract IA10: Spreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations

By Stefan F. Pinter, Yesu Jeon, Toshiro K. Ohsumi, Mark L. Borowsky, Jeannie T. Lee, Ruslan I. Sadreyev, E. Yildirim. 2012

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The Xist lncRNA exploits three-dimensional genome architecture to spread across the X-chromosome (2013, background): “3D) (44, 48): Either Xist spreads uniformly from its transcription site until it coats the entire chromosome, or Xist first localizes to “early” sites that are far from the Xist transcription locus (44).”
A Polymer Model with Epigenetic Recolouring Reveals a Pathway for the de novo Establishment and 3D organisation of Chromatin Domains (2016, background): “in this section may thus be relevant for the fascinating X-chromosome inactivation in embryonic mammalian cells [9] and, in more general terms, for the spreading of inactive heterochromatin along chromosomes [29].”
X-inactivation, imprinting, and long noncoding RNAs in health and disease. (2013, background): “From the nucleation center, PRC2 spreads initially to 150 strong binding sites along the future Xi, concentrating predominantly within bivalent domains coinciding with CpG islands (Pinter et al., 2012) (Figure 3C).”