The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit.

By D. Brodersen, W. M. Clemons, A. Carter, Robert J. Morgan-Warren, B. Wimberly, V. Ramakrishnan. Cell, 2000

904 citations recorded by the source corpus.

We have used the recently determined atomic structure of the 30S ribosomal subunit to determine the structures of its complexes with the antibiotics tetracycline, pactamycin, and hygromycin B. The antibiotics bind to discrete sites on the 30S subunit in a manner consistent with much but not all biochemical data. For each of these antibiotics, interactions with the 30S subunit suggest a mechanism for its effects on ribosome function.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/eeaa1af3556f71f75ad4101eaea8bc48aa4d0d78

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Citations in the corpus

3DNA: a software package for the analysis, rebuilding and visualization of three-dimensional nucleic acid structures. (2003, background): “The remaining ®ve examples come from other, less well-resolved ribosomal structures, rr0014 (62), rr0020 (63), rr0025 (64) and rr0052 (65), and from the 2.”
Focused classification and refinement in high-resolution cryo-EM structural analysis of ribosome complexes. (2017, result): “Pactamycin binds to the bacterial ribosomal 30S subunit [67] in a similar manner as EME to 40S.”
Versatility of Aminoglycosides and Prospects for Their Future (2003, neutral): “and hygromycin B have been solved (12, 27, 45, 117, 257, 306, 315).”
Tetracycline Antibiotics and Resistance. (2016, background): “In the T. thermophilus crystal structure, these S10 residues map to a loop projecting toward the aminoacyl-tRNA-binding site in the 30S structure (Brodersen et al. 2000; Carter et al. 2000).”