Synthesis and release of B-lymphocyte stimulator from myeloid cells.

By B. Nardelli, O. Belvedere, V. Roschke, Paul A. Moore, Henrik S. Olsen, T. Migone, S. Sosnovtseva, J. Carrell, P. Feng, J. Giri. Blood, 2001

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Subfields: Immunology

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BCMA Is Essential for the Survival of Long-lived Bone Marrow Plasma Cells (2004, result): “These observations are consistent with the observations that activated macrophages and DCs express BLyS (16).”
DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL (2002, background): “and with the ability of BLyS and APRIL to increase the proliferation and differentiation of BCR-activated B cell”
Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. (2002, background): “It is conceivable that inflammation/infection via production of inflammatory cytokines, such as IFN-γ (6), triggers BAFF secretion in affected tissues, which in turn stimulates B cell and possibly T cell responses locally as well as in neighboring lymph nodes.”
BAFF: A fundamental survival factor for B cells (2002, background): “cgi?l=3458">IFN-γ ) stimulates the expression of BAFF by these cell”