A Novel in Vivo Bioassay for (Xeno-)estrogens Using Transgenic Zebrafish

By J. Legler, J. Broekhof, A. Brouwer, P. Lanser, A. Murk, P. T. van der Saag, A. Vethaak, P. Wester, D. Živković, B. van der Burg. 2000

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Short‐term exposure to 17α‐ethynylestradiol decreases the fertility of sexually maturing male rainbow trout (Oncorhynchus mykiss) (2003, background): “When transgenic zebrafish were exposed to E2 for 48 h, the testes exhibited the highest induction of the reporter gene compared to other tissues examined [19].”
Impacts of 17β-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio) (2004, result): “This is in agreement with the study of Legler et al. (2000) who demonstrated that the estrogen receptor subtypes and are expressed very early in the development in the zebrafish (from 1 dpf) and that exposure to E2 upregulates ER-genes expression.”
Emerging contaminants in surface waters and their relevance for the production of drinking water in Europe (2010, background): “Laboratory research has shown that a large number of different chemicals can exert estrogenic effects (Blair et al. 2000; Legler et al. 2000; Nishihara et al. 2000; Houtman et al. 2004b), including the natural estrogenic hormones 17b-estradiol, estriol and estrone, the synthetic estrogenic hormone a”