A meta-analysis of alcohol drinking and cancer risk
By V. Bagnardi, Marta Blangiardo, C. Vecchia, Giovanni Corrao. British Journal of Cancer, 2001
607 citations recorded by the source corpus.
To evaluate the strength of the evidence provided by the epidemiological literature on the association between alcohol consumption and the risk of 18 neoplasms, we performed a search of the epidemiological literature from 1966 to 2000 using several bibliographic databases. Meta-regression models were fitted considering linear and non-linear effects of alcohol intake. The effects of characteristics of the studies, of selected covariates (tobacco) and of the gender of individuals included in the studies, were also investigated as putative sources of heterogeneity of the estimates. A total of 235 studies including over 117 000 cases were considered. Strong trends in risk were observed for cancers of the oral cavity and pharynx, oesophagus and larynx. Less strong direct relations were observed for cancers of the stomach, colon and rectum, liver, breast and ovary. For all these diseases, significant increased risks were found also for ethanol intake of 25g per day. No significant nor consistent relation was observed for cancers of the pancreas, lung, prostate or bladder. Allowance for tobacco appreciably modified the relations with laryngeal, lung and bladder cancers, but not those with oral, oesophageal or colorectal cancers. This meta-analysis showed no evidence of a threshold effect for most alcohol-related neoplasms. The inference is limited by absence of distinction between lifelong abstainers and former drinkers in several studies, and the possible selective inclusion of relevant sites only in cohort studies. © 2001 Cancer Research Campaign http://www.bjcancer.com
Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/ee773554b3eec820ce62cd30bac98879991aa31e
How researchers see this paper
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- V. Bagnardi
- V. Fedirko
- M. Rota
- F. Islami
- I. Tramacere
- E. Botteri
- C. Vecchia
- L. Scotti
Citations in the corpus
- Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis (2014, methodology): “It updates and expands two previous meta-analyses by our group: the first based on 235 studies, published in 2001 (Bagnardi et al, 2001), and the second, which focussed on light alcohol drinking, published in 2013 (Bagnardi et al, 2013).”
- Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. (2011, result): “The results for heavy and moderate drinking are consistent with previous pooled [7, 8] and meta-analyses [14, 15, 17]; however, the results for light drinking in these studies were either not reported or statistically nonsignificant.”