Alcohol consumption and site-specific cancer risk: a comprehensive dose–response meta-analysis
By V. Bagnardi, M. Rota, E. Botteri, I. Tramacere, F. Islami, V. Fedirko, L. Scotti, M. Jenab, F. Turati, E. Pasquali and 7 more. British Journal of Cancer, 2014
1,152 citations recorded by the source corpus.
Background:Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.Methods:We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose–response meta-regression models and investigated potential sources of heterogeneity.Results:A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose–risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin’s and Non-Hodgkin’s lymphomas were inversely associated.Conclusions:Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.
Subfields: Cancer Research, Otorhinolaryngology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/d04e920fe585b6719a8e2a3c48617aa67dd79c4c
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Citations in the corpus
- Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors (2019, background): “Moderate to heavy alcohol consumption (greater than one daily serving) are associated with increased risk of CRC [54, 55].”
- Colorectal Cancer: A Review of Carcinogenesis, Global Epidemiology, Current Challenges, Risk Factors, Preventive and Treatment Strategies (2022, background): “CRC is possible to be prevented by reducing cigarette smoking [71], excessive alcohol consumption [72], overweight or obesity [73], and the consumption of large amounts of red and processed meat [74].”