c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration

By P. Arthur-Farraj, Morwena Latouche, D. Wilton, Susanne Quintes, E. Chabrol, A. Banerjee, A. Woodhoo, B. Jenkins, Mary Rahman, M. Turmaine and 7 more. Neuron, 2012

790 citations recorded by the source corpus.

Summary The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global regulator of Wallerian degeneration. c-Jun governs major aspects of the injury response, determines the expression of trophic factors, adhesion molecules, the formation of regeneration tracks and myelin clearance and controls the distinctive regenerative potential of peripheral nerves. A key function of c-Jun is the activation of a repair program in Schwann cells and the creation of a cell specialized to support regeneration. We show that absence of c-Jun results in the formation of a dysfunctional repair cell, striking failure of functional recovery, and neuronal death. We conclude that a single glial transcription factor is essential for restoration of damaged nerves, acting to control the transdifferentiation of myelin and Remak Schwann cells to dedicated repair cells in damaged tissue.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/7cdd1ba03fad6f878b1a3dfd5aa0e6bcaa7d3ef9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

  1. R. Mirsky
  2. K. Jessen
  3. P. Yurchenco

In Developmental Neuroscience

  1. R. Mirsky
  2. K. Jessen
  3. P. Yurchenco

Citations in the corpus