Senescence in Health and Disease

By Shenghui He, N. Sharpless. Cell, 2017

1,558 citations recorded by the source corpus.

Many cellular stresses activate senescence, a persistent hyporeplicative state characterized in part by expression of the p16INK4a cell cycle inhibitor. Senescent cell production occurs throughout life and plays beneficial roles in a variety of physiological and pathological processes including embryogenesis, wound healing, host immunity and tumor suppression. Meanwhile, the steady accumulation of senescent cells with age also has adverse consequences. These non-proliferating cells occupy key cellular niches and elaborate pro-inflammatory cytokines, contributing to aging-related diseases and morbidity. This model suggests that the abundance of senescent cells in vivo predicts ‘molecular’, as opposed to chronologic, age, and that senescent cell clearance may mitigate aging-associated pathology.

Subfields: Aging, Physiology

View Paper: https://www.semanticscholar.org/paper/ee0bc18e1eb90ee8739400e6eacea15d5086f583

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Citations in the corpus

Cellular Senescence: Defining a Path Forward. (2019, neutral): “These diseases include neurodegenerative disorders, glaucoma, cataract, atherosclerosis and cardiovascular disease, diabetes, osteoarthritis, pulmonary, and renal and liver ﬁbrosis (Childs et al., 2015; He and Sharpless, 2017; Mun˜oz-Espı´n and Serrano, 2014) (Table S2).”
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “However, expression of p21WAF1/CIP1 does not persist in senescent cells as it is mainly required for induction of senescence (Stein et al., 1999; Sharpless and Sherr, 2015; He and Sharpless, 2017; Song et al., 2020).”
Cellular Senescence: Aging, Cancer, and Injury. (2019, background): “It is, therefore, possible that senescence plays a dual role during atherosclerosis: on one side, proliferative arrest of monocytes and macrophages limits plaque growth, but on the other side, SASP factors secreted from these cells can also induce disease progression (151).”
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “Mounting evidence, however, indicates that senescent cells accumulate during organismal aging due to their increased generation coupled to inefficient clearance [935, 941, 960, 961].”
Hallmarks of Cancer: New Dimensions. (2022, background): “Indeed, there are well-established examples of the protective benefits of senescence in limiting malignant progression (118, 119).”