Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis

By D. Wald, M. Law, J. Morris. British medical journal, 2002

2,104 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Pathology and Forensic Medicine, Rheumatology

View Paper: https://www.semanticscholar.org/paper/ede9c4168c5c38f2f212baf18a24a88a17a44cf1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. Sonia S Anand
2. L. Allen
3. C. Bushnell
4. C. Iadecola
5. M. Creager

In Pathology and Forensic Medicine

1. L. Allen
2. C. Iadecola
3. S. Kasner

In Rheumatology

1. L. Allen
2. Joshua D. Rabinowitz
3. Gregory S. Ducker

Citations in the corpus

• Guidelines on food fortification with micronutrients (2006, result): “While there is still some controversy concerning the direction of causality (144), a comparison of the results of genetic and prospective epidemiological studies, which would be expected to have different biases, strongly points to a direct causal pathway leading from elevated homocysteine to cardio”
• Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. (2014, background): “In 2 large meta-analyses of population-based cohort studies, a 25% (3 μmol/L) reduction in total homocysteine was associated with an 11% to 16% decrease in the risk of stroke.(646,647) In a more recent meta-analysis of clinical trials evaluating the efficacy of folate supplementation for stroke prev”
• One-Carbon Metabolism in Health and Disease. (2017, background): “These low-activity alleles are associated with a modestly increased risk of cardiovascular disorders (Casas et al., 2005; Wald et al., 2002).”
• Guidelines for the Primary Prevention of Stroke (2011, positive): “increased by 59% (95% CI, 29–96), and for each 3-μmol/L decrease in homocysteine, the odds of stroke decreased by 24% (95% CI, 15–33).(775) A further line of evidence supporting a causal role for homocysteine in a stroke is a meta-analysis of 29 studies comparing the MTHFR C677T genotype between 445”
• Facts and recommendations about total homocysteine determinations: an expert opinion. (2004, background): “In two recent large-scale metaanalyses, a 25% (3 mol/L) reduction in tHcy in population-based cohort studies was associated with a 11–16% decrease in the risk of ischemic heart disease, 19–22% decrease in the risk of stroke and 25% decrease in the risk of deep venous thrombosis (4, 145).”
• Emerging risk factors for atherosclerotic vascular disease: a critical review of the evidence. (2003, background): “low-up) do show a significant association.(95,97,98,102,103) We found only one study of the risk prediction capabilities of ho-”
• p-Causality: Identifying Spatiotemporal Causal Pathways for Air Pollutants with Urban Big Data (2016, neutral): “With the increase of computation power, variations of unitlevel causality were conducted, such as the cause-and-effect of advertising on behaviour change [8], genes on phenotype [19], etc.”
• Guidelines for management of ischaemic stroke and transient ischaemic attack 2008. (2008, background): “Vitamins which lower homocysteine (folate, B12, B6) do not appear to reduce stroke recurrence and may increase vascular events [298-301], but further trials are ongoing [302].”