NFAT signaling: choreographing the social lives of cells.

By G. Crabtree, E. Olson. Cell, 2002

1,399 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/edc1e1f483ba56b66c2e25010b30c3cb10067a4d

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In Molecular Biology

1. P. Hogan
2. F. Macian
3. Anjana Rao
4. J. Corbin
5. S. Francis

Citations in the corpus

• Transcriptional regulation by calcium, calcineurin, and NFAT. (2003, background): “Other biological systems in which NFAT is implicated NFAT is expressed in many cell types and contributes to diverse cellular functions (Crabtree and Olson 2002; Horsley and Pavlath 2002; Graef et al. 2003; Hill-Eubanks et al. 2003).”
• Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation (2003, background): “Moreover, specific inhibition of calcineurin by Cyclosporin A (CsA; Crabtree and Olson, 2002) did not block the inhibitory effect of Wnt-5a on -catenin activity and protein stability (Fig.”
• The transcription factor NFAT promotes exhaustion of activated CD8+ T cells (2015, neutral): “All NFAT proteins make very similar contacts with DNA but can have distinct expression patterns and functions as judged by the non-overlapping phenotypes ofmice deficient in individual NFAT family members (Crabtree and Olson, 2002; Hogan et al., 2003;Macian, 2005).”
• cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action (2010, background): “Activation of the NO/ cGMP/PKGI pathway counters this effect: first, PKGI has recently been shown to phosphorylate two sites (Ser322 and Thr-70) on TRPC6 (Takahashi et al., 2008; Koitabashi et al., 2010), thereby decreasing calcium entry into the cell; second, the effect of NO/cGMP/PKGI signaling to”
• NFAT proteins: key regulators of T-cell development and function (2005, background): “phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2), which generates inositol-1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG).”
• CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer. (2019, background): “NFAT is a family of transcription factors with well-established roles in T cell activation (261, 262), T cell anergy (263), and T cell exhaustion (7, 9, 122).”
• FOXP3 controls regulatory T cell function through cooperation with NFAT. (2006, neutral): “A well-known example of combinatorial transcriptional control is provided by NFAT, four calcium-regulated transcription factors (NFAT1–4) that regulate gene expression in diverse organs including the immune system, muscle, bone, and brain (Crabtree and Olson, 2002; Hogan et al., 2003).”