Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice

By A. Goodman, G. Kallstrom, Jeremiah J. Faith, Alejandro Reyes, Aimée M. Moore, Gautam Dantas, Jeffrey I. Gordon. Proceedings of the National Academy of Sciences of the United States of America, 2011

734 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/ed5086e710057be5ba30159e4343a863ff87e011

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Citations in the corpus

Microbial culturomics: paradigm shift in the human gut microbiome study. (2012, background): “The composition of the human gut microbiome, the determination of which represents a major challenge in the 21st century [1], has been studied with different tools, leading to increasingly complex results [2–6].”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “It has been reported that approximately 56% of gut bacteria detected by NGS approaches have cultured representatives (55, 56).”
Computational meta'omics for microbial community studies (2013, background): “Goodman et al (2011) showed that the human fecal microbiota consists largely of taxa and predicted functions that are represented in its readily cultured members by combining high-throughput anaerobic culturing techniques with gnoto-biotic animal husbandry and metagenomics.”
The first 1000 cultured species of the human gastrointestinal microbiota (2014, background): “, 2007), advanced culturing approaches using gnotobiotic mice (Goodman et al., 2011), or gel microdroplet culturing (Fitzsimons et al.”
Growing Unculturable Bacteria (2012, background): “In an attempt to quantify the role of the culturable and unculturable members of the gut microbiome, the group of Gordon used germfree mice as hosts for transplanted human intestinal microbial communities (29).”
A practical guide to amplicon and metagenomic analysis of microbiome data (2020, methodology): “This method has been used for micro-biome analysis in humans (Goodman et al., 2011; Zou et al., 2019), mouse (Liu et al., 2020), marine sediment (Mu et al., 2018), Arabidopsis thaliana (Bai et al., 2015), and rice (Zhang et al., 2019).”
Extensive impact of non-antibiotic drugs on human gut bacteria (2018, neutral): “Only one strain was grown in Todd-Hewitt Broth (Sigma-Aldrich), one in a 1:1 mixture of mGAM and Gut Microbiota Medium 43 and for one strain, mGAM was supplemented with 60 mM sodium formate and 10 mM taurine; see also Supplementary Table 2).”
The Rebirth of Culture in Microbiology through the Example of Culturomics To Study Human Gut Microbiota (2015, methodology): “The team of Jeffrey Gordon also demonstrated that culturing of a large repertoire of an individual’s gut microbiota by using straightforward anaerobic culturing conditions was possible (193).”
How informative is the mouse for human gut microbiota research? (2015, background): “…because it allows perturbations in a ‘human-like system’ and is considered to be the gold standard for confirming associations and trying to prove causality in gut microbiota research (Faith et al., 2011; Goodman et al., 2011; McNulty et al., 2011; Smith et al., 2013a; Turnbaugh et al., 2009b).”