In vitro hepatic differentiation of human mesenchymal stem cells

By Kuan-Der Lee, Tom K. Kuo, J. Whang-peng, Yu-Fen Chung, Ching‐Tai Lin, S. Chou, Jim‐Ray Chen, Yi-peng Chen, O. Lee. Hepatology, 2004

906 citations recorded by the source corpus.

Subfields: Genetics, Hepatology, Surgery

View Paper: https://www.semanticscholar.org/paper/ed46cb477eb2ca40090a72c9035d3fb705ad5955

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1. A. Atala
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Citations in the corpus

• Primary Hepatocytes: Current Understanding of the Regulation of Metabolic Enzymes and Transporter Proteins, and Pharmaceutical Practice for the Use of Hepatocytes in Metabolism, Enzyme Induction, Transporter, Clearance, and Hepatotoxicity Studies (2007, background): “Experiments aimed at differentiating different human extra-hepatic stem cells to hepatocytes have been performed by a relatively large number of groups (Avital et al., 2001; Eberhardt et al., 2006; Fiegel et al., 2003; Lavon et al., 2004; Lee et al., 2004; von Mach et al., 2004; Zulewski et al., 200”
• The In Vitro Migration Capacity of Human Bone Marrow Mesenchymal Stem Cells: Comparison of Chemokine and Growth Factor Chemotactic Activities (2007, background): “MSCs also generate cells that do not belong to the hematopoietic microenvironment that are mesodermal in origin, such as chondrocytes [3] and cardiac or skeletal muscle cells [5, 6], but may be also neuro-ectodermal (neurons, astrocytes, oligodendrocytes) [7, 8] or endodermal (hepatocytes) [9, 10].”
• The use of whole organ decellularization for the generation of a vascularized liver organoid (2011, methodology): “Prior research showed that liver-specific stem cells can be isolated(18,33) and differentiated to hepatic fate.(34) We used hFLCs in combination with hUVECs to recellularize the bioscaffolds, compared with adult hepatocytes used in many previous studies, Adult hepatocytes are larger and susceptible ”
• Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “Hepatocyte growth factor (HGF) and oncostatin M have been used to successfully induce human BMSCs and human UCB-MSCs to differentiate into hepatocyte-like cells [160].”