A Common Genetic Variant Is Associated with Adult and Childhood Obesity

By Alan G. Herbert, N. Gerry, M. McQueen, I. Heid, A. Pfeufer, Thomas Illig, H. Wichmann, T. Meitinger, D. Hunter, F. B. Hu and 12 more. Science, 2006

746 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Genetics, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/ece713c4635b9793d437c981e53f97ed933cb9d6

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In Genetics

Citations in the corpus

Applications of Linkage Disequilibrium and Association Mapping in Maize (2009, methodology): “For instance, in human genetics, where the association populations are collections of parent–offspring trios, two types of study design are considered: transmission disequilibrium tests (TDTs) (Spielman et al. 1993; Allison 1997; Rabinowitz 1997; Monks et al. 1998; Fulker et al. 1999) and family-bas”
The linkage disequilibrium and the selection of genetic markers for association studies in European populations (2007, background): “Current association studies use thousands or even tens of thousands of individuals to analyze the effect of disease causing alleles (Herbert et al. 2006; Sladek et al. 2007; Smyth et al. 2006).”
Overcoming the winner's curse: estimating penetrance parameters from case-control data. (2007, methodology): “Simulate genotype counts D on the basis of minor-allele frequency f and penetrances v1, v2, and v3 for a sample of n cases and n controls, according to equation (3), under the assumption of Hardy-Weinberg equilibrium in the general population.”
Mapping the Genetic Architecture of Gene Expression in Human Liver (2008, background): “Recent large-scale, genome-wide association studies have now delivered a number of novel ﬁndings across a diversity of diseases, including age-related macular degeneration [1–3], heart disease [4,5], host control of HIV-1 [6], type I and II diabetes [7,8], and obesity [9].”
Human genetics shape the gut microbiome. (2014, neutral): “Variation in host genetics can also underlie susceptibility to metabolic disease (Frayling et al., 2007; Frazer et al., 2009; Herbert et al., 2006; Yang et al., 2012).”
Applications of Linkage Disequilibrium and Association Mapping in Crop Plants (2007, neutral): “A long standing mixed model method has been used by animal scientists to analyze the data from extended pedigree in dairy or cattle breeding programs (Henderson 1975; Henderson 1976; Henderson 1984 ).”
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis (2007, methodology): “27" language="eng" relation="no"> To identify susceptibility alleles associated with rheumatoid arthritis, we genotyped 397 individuals with rheumatoid arthritis for 116,204 SNPs and carried out an association analysis in comparison to publicly available genotype data for 1,211 related ind”