The Xs and Y of immune responses to viral vaccines
By S. Klein, A. Jedlicka, A. Pekosz. Lancet. Infectious Diseases (Print), 2010
785 citations recorded by the source corpus.
The biological differences associated with an individual’s sex represent a major source of variation that impacts the immune response to vaccination. There are compelling clinical data illustrating that males and females differ in their innate, humoral, and cell-mediated responses to viral vaccines. Sex impacts the frequency and severity of adverse side effects of vaccination, including fever, pain, and inflammation. Pregnancy also can significantly alter immune responses to vaccines. Key aspects of the impact of sex and pregnancy on vaccination are presented using data drawn from clinical trials in humans as well as from animal models of vaccine efficacy and the groundwork is laid for future studies aimed at identifying the biological mechanisms, including genetic and hormonal factors, that underlie sex-specific responses to vaccines. An understanding and appreciation of the impact of sex and pregnancy on immune responses may alter the strategies used by public health officials to initiate efficient vaccination programs in the human population optimizing the timing and dose of the vaccine in order to maximize the number of people immunized, ensure sufficient levels of immune responses, minimize adverse side effects, and allow for more efficient protection of high priority populations.
Subfields: Health, Immunology, Obstetrics and Gynecology
View Paper: https://www.semanticscholar.org/paper/eccc29987098e5c848a3db70cf121914aae1efa8
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Vladimir Jojic
- Carmen Giefing-Kröll
- Mark M. Davis
- P. Berger
- David Furman
- C. Dekker
- G. Lepperdinger
- B. Grubeck‐Loebenstein
Citations in the corpus
- Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination (2013, background): “In one study, results from public gene expression data (13) showed that many of the genes induced by a yellow fever vaccine were preferentially activated in females (14).”
- Sexual Dimorphism in Innate Immunity (2019, neutral): “receptors can also regulate gene expression without directly binding to DNA but through protein-protein interactions with other DNA-binding transcription factors, such as nuclear factor-κB (NF-κB), specific protein 1 (Sp1), CCAAT/enhancer binding protein β (C/EBPβ), or activator protein 1 (AP-1), wh”
- How sex and age affect immune responses, susceptibility to infections, and response to vaccination (2015, background): “How sex and age affect immune responses, susceptibility to infections, and response to vaccination Carmen Giefing-Kröll, Peter Berger, Günter Lepperdinger and Beatrix Grubeck-Loebenstein Institute for Biomedical Aging Research of Innsbruck University, Innsbruck, Austria”