The Immune Epitope Database and Analysis Resource: From Vision to Blueprint

By Bjoern Peters, John Sidney, Philip E. Bourne, H. Bui, S. Buus, Grace Doh, Ward Fleri, M. Kronenberg, R. Kubo, Ole Lund and 9 more. PLoS Biology, 2005

309 citations recorded by the source corpus.

A planned repository of immune epitope data with associated analysis tools should be a boon to vaccine development

Subfields: Epidemiology, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ec48cbe720e1ba472f7413bd3537dd10c53383dd

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Citations in the corpus

Vaxign: The First Web-Based Vaccine Design Program for Reverse Vaccinology and Applications for Vaccine Development (2010, background): “To induce strong immunity and avoid autoimmunity, predicted vaccine targets are required not to have sequence similarity to proteins of hosts (e.g., human).”
Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines (2007, methodology): “IEDB [http://www.immuneepitope.org] 6.”
The Immune Epitope Database 2.0 (2009, background): “The IEDB makes information on all experimentally determined immune epitopes freely available to the public (1,2).”
ToxoDB: an integrated Toxoplasma gondii database resource (2007, background): “A mapping of immune epitopes identified in Toxoplasma provided by the Immune Epitope Database and Analysis Resource (IEDB) (11) has been integrated.”
High-throughput prediction of protein antigenicity using protein microarray data (2010, background): “For Permissions, please email: journals.permissions@oxfordjournals.org at H eF eiU niversity ofT echnology on N ovem ber 27, 2010 bioinform atics.oxfordjournals.org D ow nloaded from [09:45 30/10/2010 Bioinformatics-btq551.tex] Page: 2937 2936–2943 for the antigens most likely to elicit a…”
Improved method for predicting linear B-cell epitopes (2006, methodology): “Future work could include using data from other sources, such as the Immune Epitope Database and Analysis Resource, IEDB [15], or the Epitome database of structurally inferred antigenic epitopes in proteins http:// www.”
A Systematic Assessment of MHC Class II Peptide Binding Predictions and Evaluation of a Consensus Approach (2008, methodology): “This assessment was confirmed by comparing our dataset to publicly available records contained in the IEDB (Table 1) or elsewhere.”
Immune epitope database analysis resource (IEDB-AR) (2008, background): “The IEDB-AR covers a broad range of tools facilitating the prediction of new B- and T-cell epitopes in proteins of interest, and tools for the analysis of epitope sets collected from within the IEDB (1) or submitted by the user.”