Development of an epitope conservancy analysis tool to facilitate the design of epitope-based diagnostics and vaccines
By H. Bui, John Sidney, Nicholas Fusseder, Alessandro Sette. BMC Bioinformatics, 2007
525 citations recorded by the source corpus.
BackgroundIn an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions. Conversely, in a diagnostic and disease monitoring setting, epitopes that are specific to a given pathogen strain, for example, can be used to monitor responses to that particular infectious strain. In both cases, concrete information pertaining to the degree of conservancy of the epitope(s) considered is crucial.ResultsTo assist in the selection of epitopes with the desired degree of conservation, we have developed a new tool to determine the variability of epitopes within a given set of protein sequences. The tool was implemented as a component of the Immune Epitope Database and Analysis Resources (IEDB), and is directly accessible at http://tools.immuneepitope.org/tools/conservancy.ConclusionAn epitope conservancy analysis tool was developed to analyze the variability or conservation of epitopes. The tool is user friendly, and is expected to aid in the design of epitope-based vaccines and diagnostics.
Subfields: Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/12210299feb0cd5577e8e012b22a0e950d5759d6
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In Immunology
In Molecular Biology
- Morten Nielsen
- Bjoern Peters
- Alessandro Sette
- Ole Lund
- J. Greenbaum
- Claus Lundegaard
- Massimo Andreatta
- Peng Wang
In Radiology, Nuclear Medicine and Imaging
- Morten Nielsen
- Bjoern Peters
- Alessandro Sette
- Claus Lundegaard
- Ole Lund
- J. Greenbaum
- Massimo Andreatta
- Sinu Paul
Citations in the corpus
- Immune epitope database analysis resource (IEDB-AR) (2008, background): “In an epitope-based vaccine setting, the use of conserved epitopes would be expected to provide broader protection across multiple strains, or even species, than epitopes derived from highly variable genome regions (25).”
- The UCSC Genome Browser database: 2021 update (2020, methodology): “Amidst the coronavirus pandemic, the SARS-CoV-2 assembly browser was added with datasets from major annotation databases: Protein Data Bank (12), non-coding RNA families (13), Immune Epitope Database (14), Global Initiative on Sharing All Influenza Data (GISAID) (15), and Universal Protein Resource ”