Induction of small cell lung cancer by somatic inactivation of both Trp53 and Rb1 in a conditional mouse model.

By R. Meuwissen, S. Linn, R. Linnoila, J. Zevenhoven, W. Mooi, A. Berns. Cancer Cell, 2003

598 citations recorded by the source corpus.

Subfields: Epidemiology, Oncology

View Paper: https://www.semanticscholar.org/paper/ebf261ba0ec14113ef684e776c2f116b0b726195

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Julien Sage
2. Deborah L. Burkhart

In Oncology

1. T. Jacks
2. D. Cobrinik
3. R. Weinberg
4. D. Hanahan

Citations in the corpus

• Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase (2009, background): “A model of small cell lung cancer (SCLC) has been created, in which tumors arise after the loss of both p53 and retinoblastoma (Rb) tumor suppressor”
• Cellular mechanisms of tumour suppression by the retinoblastoma gene (2008, background): “gov/cancertopics/types/lung/">small-cell lung carcinomas (SCLC), and mouse genetic studies have confirmed that RB is crucial in preventing the initiation of this lung cancer subtyp”
• Pocket proteins and cell cycle control (2005, background): “For example, loss of pRB in the lung resulted in aberrant proliferation and mild hyperplasia, whereas combined loss of pRB and p53 resulted in small cell lung carcinomas (Meuwissen et al., 2003; WikenheiserBrokamp, 2004).”